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What is intrathecal baclofen therapy, and how does it fit into the spectrum of spasticity management options for individuals with spinal cord injury?
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The proximal catheter was connected to an implanted osmotic mini pump so that drug solution could be continuously infused.
Following discontinuation of the drug, REM sleep rebound has been reported in some studies.
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Due to the side effects associated with baclofen, its overall usefulness is somewhat limited.
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Very often the maintenance dose needs to be adjusted during the first few months of therapy while patients adjust to changes in life style due to the alleviation of spasticity.
Patients who are unresponsive to oral baclofen or who experience intolerable central nervous system (CNS) side effects from oral medications may benefit from ITB Therapy SM.
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Overall, we believe this initial clinical experience suggests that baclofen is a well tolerated and safe medication that may effectively help to retain patients in treatment for clinically relevant periods and reduce their cocaine use.
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Nine patients discontinued long term treatment due to adverse events.
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See full prescribing information for complete boxed warning Abrupt discontinuation of intrathecal baclofen, regardless of the cause, has resulted in sequelae that include high fever, altered mental status, exaggerated rebound spasticity, and muscle rigidity, that in rare cases has advanced to rhabdomyolysis, multiple organ-system failure and death.
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Baclofen is currently being tested as a potential treatment to help provide relief for the withdrawal symptoms associated with cocaine use.
Baclofen Injection (Intrathecal) is for use in single bolus intrathecal injections (via a catheter placed in the lumbar intrathecal space or injection by lumbar puncture) and in implantable pumps approved by the FDA specifically for the intrathecal administration of baclofen.
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