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Hu S, Wang S, Fanelli B, Bell PA, Dunning RE, Geisse S, Schmitz R, Boettcher BR: Pancreatic β-cell channel activity and membrane-binding studies with nateglinide: a comparison with sulfonylureas and repaglinide.

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Although combinatorial chemistry in one or more of its manifestations has now been present as a discovery source for approximately 80% of the time covered by this review, to date, we still can only find one formal de novo new chemical entity reported in the public domain, with a second possibility discovered in a similar manner, with both approved for drug use.

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Ratner RE, Maggs D, Nielsen LL, Stonehouse AH, Poon T, Zhang B et al.

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Rosenstock J, Zinman B, Murphy LJ, Clement SC, Moore P, Bowering CK, Hendler R, Lan S-P, Cefalu WT: Inhaled insulin improves glycemic control when substituted for or added to oral combination therapy in type 2 diabetes.

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Western Cape. South Africa
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